The basophil

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Basophil production.

Factors influencing basophil production from the bone marrow of ovalbumin (OA)-sensitized guinea pigs have been examined in vitro. Autologous co-cultures of marrow and spleen cells from OA-immune animals contained significantly higher numbers of basophils after 7 d of liquid culture in the presence of OA, compared with control co-cultures or with marrow cultures alone (P < 0.005). Basophils inc...

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When is a mouse basophil not a basophil?

The identification and characterization of mouse basophils have historically been hampered by the extreme rarity of this cell type. Virtually no photomicrographs of hematologically stained (eg, Wright-Giemsa) examples of mouse basophils exist in the literature. However, 4 recent studies in the past 2 years have used flow cytometry and a defined set of cell-surface markers to identify and subseq...

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Optimizing of the basophil activation test: Comparison of different basophil identification markers.

BACKGROUND Flowcytometric identification of basophils is a prerequisite for measuring activation of basophils with IgE-dependent or IgE-independent stimuli. Aim of this study was to compare different marker combinations in a simultaneous multicolor flowcytometric measurement. METHODS Ten patients with a grass pollen allergy and three controls were included in the study. Basophilic cells were ...

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The expanding universe of the basophil.

Interest in the role of basophils in immune responses has been rejuvenated recently. Demonstration of their ability to promote humoral memory responses,1 drive IgEdependent dermatitis, 2 and shift an immune response toward TH-2– dominated inflammation3,4 are some of the many biologic activities described. In this issue, Ohnmacht and Voehringer address the development and lifespan of basophils a...

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Cutaneous Basophil Hypersensitivity

Delayed onset erythematous skin reactions elicited in guinea pigs early in the course of sensitization with azobenzenearsonate-protein conjugates or with protein antigens in incomplete Freund's adjuvant or in saline were found to have a characteristic morphology which sets them apart from delayed hypersensitivity and the classic antibody mediated reactions. The principle feature was massive der...

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ژورنال

عنوان ژورنال: General Internal Medicine and Clinical Innovations

سال: 2020

ISSN: 2397-5237

DOI: 10.15761/gimci.1000186